Food and agriculture are at the heart of civilization and prosperity. Yet, agriculture faces multiple challenges: a world population expected to grow to 9 billion by 2050, smaller rural labor force, soil quality degradation, climate change, food wastage, water scarcity, biofuel production and changing lifestyles leading to urbanization and more protein-intensive diets. Furthermore, agricultural productivity increases would ensure food security for everyone only if access to safe, nutritious and sufficient food is secured. The growing pressure on global food systems constitutes a critical development challenge and creates an increased risk for businesses, governments, communities and the environment. In this context, the business has become a critical partner for governments and other stakeholders to design and deliver effective, scalable and practical solutions for secure and sustainable food and agriculture system. Business can contribute to solving these challenges, eradicating hunger and improving food and agriculture systems. Implementing sustainable practices and working in partnership with other actors throughout the agricultural value chain (including input, production, distribution, and retail) will be key to the implementation of SDG2. In particular, empowering small farmers, increasing agricultural productivity and farmers’ livelihoods, raising consumers’ awareness and increasing agricultural investment, as well as knowledge sharing, will be necessary elements of better functioning food and agriculture systems.